Frame-Shifted Synthesis of Oligoheterocycles as a Platform for Molecular Design.

ABSTRACT: Chemists continue to develop strategies that leverage abundant feedstocks to accelerate the production of medicines, agrochemicals, and materials. Oligoheterocycles are a broad class of molecules that span these disciplines. Cross-coupling strategies are commonly used to assemble oligoheterocycles; however, these methods can be challenging and often rely on precious metal catalysts and building blocks whose production entails significant environmental and economic costs. We present a strategy for the iterative construction of oligoheterocycles that leverages sustainable building blocks designed around high-oxidation-state carbon. By utilizing feedstocks from the base of the chemical supply chain, we generate bifunctional building blocks that chemoselectively engage with a variety of partne

SUBMITTER: Bastick KAC 

PROVIDER: S-EPMC12790365 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature