Fibulin 2 Deficiency Drives Epigenetic Hypertension.

ABSTRACT:

Background

Although epigenetic modification of histone in embryonic development is well documented, its mechanistic role in the pathogenesis of hypertension is poorly understood. The purpose of this study is to investigate how histone 3 modification (H3K27me3 [trimethylation of histone 3 lysine 27]) in renal tubule cells regulates sodium excretion and blood pressure.

Methods

A mouse model of inducible renal tubule cell-specific deletion of KDM6A cKO (histone 3 lysine 27 demethylase 6A gene) was generated.

Results

Here, we uncovered the potential role of FBLN2 (fibulin 2) in the pathogenesis of epigenetic hypertension due to KDM6A cKO. KDM6A is a specific demethylase for H3K27me3. ChIP-seq analysis revealed that the H3K27me3 mark was increased in the promoter region of

SUBMITTER: Han X 

PROVIDER: S-EPMC12790445 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature