SREBP2 confers ferroptosis resistance by targeting GPX4 in colorectal cancer.

ABSTRACT:

Background

The upregulated expression of sterol regulatory element-binding protein 2 (SREBP2) has been observed in multiple types of malignant cancers. Ferroptosis is a form of cell death that is iron-dependent and driven by the accumulation of lipid peroxides. It has recently garnered considerable attention in Colorectal cancer (CRC) research. This study aims to investigate the role of SREBP2 in CRC ferroptosis resistance and the underlying molecular mechanisms.

Methods

SREBP2 expression was assessed in CRC. Functional assays were conducted in HT29 and RKO cells following SREBP2 knockdown or treatment with Betulin, the SREBP2 inhibitor. RNA-seq was used to screen the potential downstream targets of SREBP2. Mechanistically, ferroptosis-related markers and rescue assays revea

SUBMITTER: Zhong H 

PROVIDER: S-EPMC12790512 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature