Beyond beta rhythms: subthalamic aperiodic broadband power scales with Parkinson's disease severity-a cross-sectional multicentre study.

ABSTRACT:

Background

Parkinson's disease is linked to increased beta rhythms (13-30 Hz) in the subthalamic nucleus, which correlate with motor symptoms. However, findings across studies are inconsistent. Furthermore, the contribution of other frequencies to symptom severity remains underexplored.

Methods

We analysed subthalamic local field potentials from 119 patients with Parkinson's disease (31 female; mean age 60 ± 9 years) across five independent datasets. Power spectra were parametrised and studied in relation to Levodopa administration and the severity of motor symptoms.

Findings

Our findings suggest that small sample sizes contributed to the variable correlations between beta power and motor symptoms reported in previous studies. Here, we demonstrate that more than 100 p

SUBMITTER: Gerster M 

PROVIDER: S-EPMC12790593 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature