Acaricidal activity of small molecule antagonists of the tick kinin receptor against Rhipicephalus microplus acaricide-susceptible and resistant strains.

ABSTRACT:

Background

Resistance to acaricides underscores the need for tick control alternatives. We previously identified in a high-throughput screen six small molecules SACC-0412060, SACC-0412062, SACC-0412066, SACC-0064443, SACC-0428788, and SACC-0039590 as antagonists of the kinin receptor from Rhipicephalus microplus. The acaricidal activity of these molecules was investigated.

Results

The toxicities of adjuvant/solvent combinations of a rapeseed oil methyl ester or a propylene carbonate in 5% DMSO versus 5% DMSO alone were evaluated using a larval immersion test (LIT) with the R. microplus susceptible Deutch strain, and all were non-toxic. The rapeseed oil methyl ester (1%) in 5% DMSO was adopted as the adjuvant for all molecules in bioassays. Permethrin (3.19 mM) killed all lar

SUBMITTER: Arafa WM 

PROVIDER: S-EPMC12790644 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature