Rhesus testing and anti-D prophylaxis in RhD-negative women undergoing first-trimester abortion-Systematic Review and Opinion.

ABSTRACT:

Background

The introduction of immunoglobulin G (IgG) anti-D prophylaxis for Rhesus D (RhD)-negative women has substantially reduced the incidence of RhD alloimmunization and hemolytic disease of the fetus and newborn in Europe by 85%, transforming fetal health outcomes. However, there is little evidence for the need of giving IgG anti-D prophylaxis to RhD-negative women in first-trimester abortions.

Objectives

To analyze the international and national evidence-based guidelines on Rh testing and anti-D prophylaxis in first-trimester abortion, along with current literature both supporting and opposing this practice, to facilitate informed decision making in clinical practice.

Search strategy

A systematic search was conducted in Pubmed/MEDLINE, EMBASE, Cochrane Library,

SUBMITTER: Gemzell-Danielsson K 

PROVIDER: S-EPMC12790671 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature