Cell networks in the mouse liver during partial hepatectomy.

ABSTRACT: In solid tissues, homeostasis and post-injury regeneration involve a complex interplay among various cell types. The mammalian liver harbors numerous epithelial and non-epithelial cells, and the global signaling networks governing their interactions are unknown. To unravel the hepatic cell network, we purified 10 different cell populations from normal and regenerative mouse livers. Analyzing their transcriptomes unveiled ligand-receptor interactions and over 50,000 potential cell-cell interactions in both ground state and after partial hepatectomy. Importantly, about half of these differed between the two states, indicating massive changes in the cell network during regeneration. Our study provides the first comprehensive database of potential cell-cell interactions in liver cell homeostas

SUBMITTER: Li B 

PROVIDER: S-EPMC12790737 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature