Risk of major depression in partners of people with Alzheimer's disease: a national cohort study.

ABSTRACT:

Background

Alzheimer's disease (AD) may cause significant psychosocial distress not only in the patient but also their partner. However, long-term risks of major depression in partners of AD patients are largely unknown.

Methods

A national cohort study was conducted of all 145 289 partners of people diagnosed with all-cause dementia, including 57 113 partners of people diagnosed with AD, in Sweden during 1998-2017, and 1 300 561 population-based controls. Cox regression was used to compute hazard ratios (HRs) for subsequent risk of major depression identified from nationwide outpatient and inpatient diagnoses through 2018, adjusting for sociodemographic factors and prior mental disorders.

Results

The 10-year cumulative incidence of major depression was 5.4% in partner

SUBMITTER: Crump C 

PROVIDER: S-EPMC12790763 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature