Loss of antiphospholipid antibody positivity decreases the risk of recurrent thrombosis in thrombotic antiphospholipid syndrome.

ABSTRACT:

Objective

To establish the predictive value of antiphospholipid antibody (aPL) negativization on recurrent thrombosis in thrombotic antiphospholipid syndrome (APS).

Methods

Retrospective cohort study including all consecutive adult patients with APS followed at Hospital de Santa Maria, Lisbon, Portugal, up to December 2024. At diagnosis, all patients were positive for solid-phase aPL. Then, patients were categorized in two groups according to aPL during follow-up: (i) persistently aPL-positive; (ii) aPL-negativization defined as previous aPL-positive and current aPL-negative (two consecutive times, ≥12 months apart). Outcomes included recurrent thrombosis under antithrombotic therapy. Predictors of aPL-negativization and recurrent thrombosis were assessed using Cox regressio

SUBMITTER: Gaspar P 

PROVIDER: S-EPMC12790813 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature