Effects of Short-Term Intensive Insulin Therapy Combined With Oral Hypoglycemic Agents for Inducing Remission in Newly Diagnosed Type 2 Diabetes Mellitus: A Randomized Clinical Trial.

ABSTRACT:

Aims

To investigate the effects of combining oral hypoglycemic agents with short-term intensive insulin therapy (SIIT) via continuous subcutaneous insulin infusion (CSII) on glycemic outcomes in adults with newly diagnosed type 2 diabetes mellitus.

Materials and methods

In this multicenter, open-label trial, 245 participants were randomized to three treatment arms: SIIT for 2 weeks (CSII group), SIIT plus 90-day metformin and pioglitazone (CSII + Met + Pio group), or SIIT plus 90-day sitagliptin (CSII + Sita group). The primary outcome was the 12-month diabetes remission rate. Parameters of glycemic control, β-cell function, and insulin resistance were compared among groups.

Results

The participants had a mean HbA1c of 10.6% ± 2.2%. Compared to the CSII group, both co

SUBMITTER: Ke W 

PROVIDER: S-EPMC12790882 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature