Regioselective synthesis of novel spiro-isoxazolines congeners as antimicrobial agents: <i>in vitro</i> and <i>in-silico</i> assessments.

ABSTRACT:

Introduction

A new class of spiroisoxazolines was efficiently synthesized through a regioselective cycloaddition between arylidene tetralone 1 and arylnitrile oxides 2, characterized and assessed for their in vitro antimicrobial activity.

Methods

The structures and regioselectivity of the obtained cycloadducts were confirmed by 1H, 13C-NMR, IR, elemental analysis, and mass spectrometry, and further supported by theoretical calculations that explained the reaction process and the regioselective results. The antimicrobial profile of the synthetized spiro derivatives was evaluated against the yeast Candida albicans, the Gram-postive bacteria (Staphylococcus aureus and Bacillus subtilis), and the Gram-negative bacteria (Escherichia coli and Pectobacterium

SUBMITTER: Bouzammit R 

PROVIDER: S-EPMC12791170 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature