Lipid biomarkers of habitual alcohol intake and associations with pancreatic cancer risk.

ABSTRACT:

Background

Evidence supports a modest positive association between alcohol intake and pancreatic ductal adenocarcinoma (PDAC); however, knowledge regarding mechanisms underlying the association is scarce. Investigation of lipidomic metabolites may provide mechanistic insights into this association.

Methods

We measured 611 lipid species across 14 lipid classes in serum samples collected up to 24 years before PDAC diagnosis in 2 nested case-control studies (706 matched sets) within American and Finnish cohorts. We conducted cross-sectional analyses using multivariable linear regressions to examine associations between log-transformed self-reported alcohol intake and log-transformed lipid concentrations among controls within each cohort. The identified alcohol-associated lipids

SUBMITTER: Mitra PR 

PROVIDER: S-EPMC12794230 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature