Complex regional pain syndrome evolution is determined by both biological and psychosocial factors: a 1-year prospective observational study.

ABSTRACT:

Abstract

Complex regional pain syndrome (CRPS) is a challenging condition with unpredictable clinical evolution. Identifying early prognostic factors could transform patient management and improve outcomes. This prospective study followed 113 patients with early CRPS (<6 months) over 1 year to assess clinical evolution and investigate key predictors of chronification. Participants underwent repeated clinical assessments, quantitative sensory testing, and self-reported evaluations at 4 time points over 1 year. Multivariable mixed-effect models were used to identify independent early prognostic factors. Despite some improvement, 35% of the participants still met Budapest criteria at 1 year, with persistent pain, disability, and impaired quality of life. Sensory profiles appeared to s

SUBMITTER: Louis MH 

PROVIDER: S-EPMC12794358 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature