Immune cell signatures and preeclampsia: Unveiling causal links through genome-wide association studies.

ABSTRACT: The immune-placental interaction could potentially contribute both causally and therapeutically to preeclampsia (PE). However, previous observational studies have not demonstrated a causal association between these 2 factors. Exploring the causal relationship between immune cells and PE provides genetic evidence that immune cells play a role in PE risk. Using a large dataset of genome-wide association studies, we conducted a bidirectional Mendelian randomization (MR) analysis to determine whether 731 immune cell signatures were correlated with PE, which included 4 types of immune signatures. After false discovery rate (FDR) correction, 3 immunophenotypes were identified to be significantly associated with PE risk: human leukocyte antigen on dendritic cells (odds ratio [OR] = 1.072, 95% con

SUBMITTER: Zhang H 

PROVIDER: S-EPMC12795097 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature