Personality disorders and cardiometabolic diseases: A Mendelian randomization study.

ABSTRACT: Observational studies have suggested the associations between personality disorders (PDs) and cardiometabolic diseases (CMDs), though these may be biased by unmeasured confounding, including lifestyle factors or reverse causality. Mendelian randomization (MR) provides a novel approach to address these limitations by using genetic variants as instrumental variables, thereby minimizing environmental confounding and enabling causal inference. This study leverages MR to systematically evaluate causal relationships across 9 clinically relevant PDs and 8 major CMDs, offering genetic evidence to clarify previously observed epidemiological associations. Data for 9 kinds of PDs (including anankastic personality disorder, anxious personality disorder, dependent personality disorder, dissocial person

SUBMITTER: Yang W 

PROVIDER: S-EPMC12795098 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature