Yersinia pseudotuberculosis produces a cytotoxic necrotizing factor.

ABSTRACT: Cell extracts from Yersinia pseudotuberculosis induced multinucleation in HEp-2 cells in a manner similar to the effect caused by Escherichia coli cytotoxic necrotizing factor (CNF). The activity was not dependent on the Yersinia 70-kb virulence plasmid, and the activity was not inhibited by antibodies capable of neutralizing E. coli CNF type 1. The nucleotide sequence of the Yersinia cnf gene was 65.1% identical to the E. coli cnf gene.

SUBMITTER: Lockman HA 

PROVIDER: S-EPMC127951 | biostudies-literature | 2002 May

REPOSITORIES: biostudies-literature