Prominent mediatory role of gut microbiome in the effect of lifestyle on host metabolic phenotypes.

ABSTRACT: Lifestyle factors influence both gut microbiome composition and host metabolism, yet their combined and mediating effects on host phenotypes remain poorly characterized in cardiometabolic populations. In 1,643 participants from the MetaCardis study, we developed a composite lifestyle score (QASD: dietary quality, physical activity, smoking, and diet diversity) that outperformed individual lifestyle variables in explaining microbial gene richness and exhibited a significant impact on the gut microbiome composition. While bidirectional pathways linking the QASD score, host phenotypes, and microbiome composition were assessed, causal inference-based mediation analyses indicated stronger effects when the microbiome was modeled as the mediator variable, particularly in relation to the insulin r

SUBMITTER: Adriouch S 

PROVIDER: S-EPMC12795280 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature