Association between diabetic retinopathy and neurodegenerative diseases in the All of Us research program.

ABSTRACT:

Purpose

While diabetic retinopathy (DR) has previously been linked to neurodegenerative diseases, it remains unclear whether DR independently reflects neurodegenerative diseases beyond those attributable to diabetes itself. In this study, we leveraged data from the All of Us Research Program to assess whether DR serves as an independent marker of neurodegenerative disease among individuals with diabetes.

Methods

A matched case-control, cross-sectional study was conducted using data from the All of Us Research Program (US-based EHR database). Three groups (exactly matched by age, sex, and race) were created and compared: individuals with both DR and DM (DR+DM, n = 7629), individuals with DM but no DR (DM-only, n = 22,887), and individuals without DM (n =

SUBMITTER: Yu HN 

PROVIDER: S-EPMC12795579 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature