Metabolomic biomarkers of rest-activity rhythms in older women: results from the Women's Health Initiative study.

ABSTRACT:

Study objectives

Prior research has suggested that disrupted and weakened rest-activity rhythms measured by accelerometry may be associated with risks of many diseases, including cardiometabolic diseases, cancer, and dementia, but the mechanisms underlying this are not fully understood. This study is the second of two studies aimed at using an untargeted approach to identify metabolomic markers associated with rest-activity rhythm characteristics and focuses on older women.

Methods

The analysis included 688 women in the Women's Health Initiative. Rest-activity rhythms were characterized by parametric and non-parametric algorithms applied to accelerometry data. Metabolomics data were measured from fasting serum samples with ultra high-performance liquid-phase chromatography a

SUBMITTER: Zhang L 

PROVIDER: S-EPMC12795739 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature