Metabolomic biomarkers of rest-activity rhythms in older men: results from the Osteoporotic Fractures in Men (MrOS) study.

ABSTRACT:

Study objectives

Rest-activity rhythm characteristics have been linked to a wide range of health conditions; however, the molecular mechanisms underlying these associations are not well understood. This study is the first of two studies aiming to use an untargeted approach to identify metabolomic markers associated with rest-activity rhythm characteristics and focuses on older men.

Methods

The study included 950 participants from the Osteoporotic Fractures in Men study. Multiple parametric and non-parametric variables of rest-activity rhythms were derived from actigraphy data. A total of 848 metabolites were measured from fasting blood samples using an untargeted approach. Multiple linear regression models and Ingenuity Pathway Analysis (IPA) were used to identify metabolomi

SUBMITTER: Zhang L 

PROVIDER: S-EPMC12795748 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature