CSN5 overexpression promotes the integral progression of cervical cancer by enhancing ENO3-mediated glycolysis.

ABSTRACT: Cervical cancer (CC) remains a significant global health challenge. A deeper understanding of the molecular mechanisms driving CC progression is crucial for developing improved therapeutic strategies. CSN5 is vital in cell functions and cancer, but its role in CC is unclear. This study aims to explore CSN5's role and its target gene in CC progression, assessing their potential as therapeutic targets. We employed an integrated approach combining bioinformatics analysis, proteomic profiling, and in vitro and in vivo functional assays. Immunohistochemistry was used to analyze CSN5 and ENO3 expression in CC and normal tissues. CSN5 upregulation was associated with advanced clinical stage and poor differentiation. Furthermore, CSN5 overexpression enhanced cellular proliferation and glycolytic m

SUBMITTER: Cao Z 

PROVIDER: S-EPMC12795886 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature