Blood ctDNA-specific markers predict the risk of peritoneal metastasis for advanced gastric cancer.

ABSTRACT:

Objective

The aim of this study was to investigate the value of early postoperative ctDNA dynamic monitoring (TP53/KRAS/PIK3CA gene mutations) combined with clinicopathologic factors in risk stratification of postoperative peritoneal metastasis in advanced gastric cancer.

Methods

One hundred and twenty-eight patients with advanced gastric cancer (stage II/III) who underwent R0 resection were enrolled, of whom 32 developed peritoneal metastasis after surgery (peritoneal metastasis group) and 96 did not (non-peritoneal metastasis group). The study collected peripheral blood samples from patients at 7 days (T0) and 4 weeks (T1) after surgery, detected mutations in ctDNA at three loci, TP53 p.R248W, KRAS p.G12D, and PIK3CA p.H1047R, by ddPCR and simultaneously collected clinicop

SUBMITTER: Xing F 

PROVIDER: S-EPMC12796062 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature