Genome-annotated bivariate analysis of shared heritability in autoimmune hepatitis with psychiatric comorbidity.

ABSTRACT: Studies indicate a high psychiatric burden in autoimmune hepatitis (AIH) patients, yet research on their genetic links remains unclear. This study comprehensively explores their genetic connections. The correlation metric, genetic correlation (rg), can measure the shared biological basis and explore the genetic architecture. We used the summary statistics from genome-wide association studies (GWAS) to accurately calculate the global and bivariate local genetic correlations between AIH and psychiatric disorders. Cross-trait GWAS meta-analysis for multiple traits can efficiently evaluate single nucleotide polymorphism (SNP) level summary statistics. We employ molecular characteristics to conduct unit tests in various tissues and annotate the corresponding loci. Through multiple genetic covar

SUBMITTER: Liu L 

PROVIDER: S-EPMC12796253 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature