Engineered biodegradable polymeric nanoparticles injectable system of atorvastatin for improved therapeutic activity.

ABSTRACT: Carrier-mediated drug delivery is one of the potential approaches employed to increase drug solubility and bioavailability. Atorvastatin (ATR), a HMG CoA reductase inhibitor, is a first-line medication prescribed for the treatment of hyperlipidemia and related cardiovascular diseases. The efficacy of ATR is highly limited due to its poor solubility and low oral bioavailability. In the present study, an injectable system of ATR-loaded polymeric nanoparticles was synthesized through the spray drying technique using chitosan polymer extracted in-house from a novel source of Portunus Sanguinolentus species shells. The effect of spray dryer nozzle diameter and polymer concentration on particle size, morphology, in vitro drug release, and ex vivo permeation was studied. The synthesized ATR-loade

SUBMITTER: Venkatraman R 

PROVIDER: S-EPMC12796266 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature