Acceptance of preventive therapy for latent tuberculosis infection in Chinese children and adolescents: a systematic review and meta-analysis.

ABSTRACT: Tuberculosis preventive treatment (TPT) is essential for pediatric tuberculosis control in children and adolescents. Evidence indicates most attrition occurs prior to TPT initiation rather than from post-initiation nonadherence. This study systematically evaluated TPT acceptance for latent tuberculosis infection (LTBI) among Chinese children and adolescents and identified key influencing factors through comprehensive database searches (PubMed, Web of Science, Embase, Cochrane, CNKI, Wanfang database, CBM, VIP) up to February 21, 2025. The heterogeneity was assessed using I² statistics (95.770%, P < 0.001), with random-effects models employed for meta-analysis. Subgroup, meta-regression, and sensitivity analyses were performed to identify the sources of heterogeneity. Begg and Eg

SUBMITTER: Peng L 

PROVIDER: S-EPMC12796291 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature