Long non-coding RNA lncAPAT promotes atherosclerotic plaque instability by targeting ribosomal protein L22.

ABSTRACT:

Background

Long non-coding RNAs (lncRNAs) regulate macrophage inflammation and atherosclerotic plaque stability, but mechanisms need comprehensive investigations.

Methods

Whole-transcriptome sequencing was used to identify a novel human-specific lncRNA, lncAPAT (atherosclerotic plaque instability-associated transcript), in the peripheral blood of patients with coronary artery disease (CAD; n = 5) with mixed plaques on coronary computed tomography angiography (CCTA). LncAPAT was quantified using quantitative real-time polymerase chain reaction in the discovery cohort and independently validated in patients with coronary mixed plaques by CCTA (n = 22) and in patients with acute ST-segment elevation myocardial infarction (STEMI; n = 22). Myeloid cell-specific lncAPAT knock-in m

SUBMITTER: Li R 

PROVIDER: S-EPMC12796838 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature