UMI-77 Ameliorates Lipopolysaccharide-Induced Sepsis-Associated Encephalopathy by Modulating the Brain-Gut Axis.

ABSTRACT:

Purpose

Sepsis-associated encephalopathy (SAE) is a common neurological complication of sepsis. UMI-77 has shown unique benefits in modulating inflammation to improve sepsis. However, the exact role of UMI-77 in the treatment of SAE and its mechanism are unknown.

Aim

This article analyzes UMI-77 based on metabolomics and explores its mechanism of action in treating SAE based on the brain-gut axis.

Method

In this study, hematoxylin and eosin (H&E) and immunofluorescence staining were used to evaluate the therapeutic effect of UMI-77 on SAE mice. Applying untargeted metabolomics analysis, the metabolic changes in the brain and intestines of septic mice treated with UMI-77 were examined. Furthermore, Receiver Operating Characteristic (ROC) analysis was used to select pre

SUBMITTER: Ke Y 

PROVIDER: S-EPMC12796848 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature