Intraoperative Genicular Nerve Infiltration Offers Comparable Pain Control to Traditional Periarticular Injection After Total Knee Arthroplasty: A Randomized Controlled Trial.

ABSTRACT:

Background

Postoperative pain in total knee arthroplasty (TKA) can hinder rehabilitation and impair functional outcomes. Periarticular injection (PAI) is commonly used method to mitigate postoperative pain. However, the optimal injection sites and volumes remain inconclusive. Genicular nerve infiltration (GNI), targeting 3 of the 6 primary genicular nerve branches, has shown promise in nonoperative osteoarthritis treatment. This study aimed to evaluate the efficacy of intraoperative PAI with GNI in reducing postoperative pain following TKA.

Methods

This single-center, double-blinded, 3-arm randomized controlled trial enrolled 78 patients undergoing unilateral TKA (n = 26 per group). Patients were randomized to receive no injection (control), traditional PAI, or PAI with GNI

SUBMITTER: Phaliphot J 

PROVIDER: S-EPMC12796858 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature