Heterogeneity in Lumbar Segmental Bone Mineral Density and Age-Related Evolution of Whole-Body Bone Mineral Density: Comprehensive Implications for Osteoporosis Risk Assessment.

ABSTRACT:

Objective

This study aimed to analyze the bone mineral density (BMD) in various body regions, investigate the effects of age and sex on BMD, and characterize BMD variations among different lumbar segments (L1-L4). Thereby uncovering patterns of regional bone loss, quantifying heterogeneity risks, and dynamically tracking individual trajectories.

Methods

BMD was measured using dual-energy x-ray absorptiometry (DXA). Patients were stratified to analyze the effects of age and sex on BMD at the following sites: lumbar spine (L1-L4); femur: Ward's triangle, greater trochanter, femoral shaft, femoral neck, upper femoral neck, and lower femoral neck; and head, ribs, and pelvis. Subgroup analyses were conducted based on age, BMD Z-scores, BMD T-scores, and body mass index (BMI) to c

SUBMITTER: Zhang JJ 

PROVIDER: S-EPMC12796975 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature