Competition between binding partners of yeast Pex3 affects peroxisome biology.

ABSTRACT: Peroxisomes are important membrane-bound organelles that are involved in a multitude of metabolic processes. Peroxisomal biogenesis factor 3 (Pex3) is a crucial peroxisomal membrane protein (PMP) that plays a vital role in many of these processes through the specific recruitment of several binding partners. In the yeast Hansenula polymorpha, Pex3 recruits PMP import receptor Pex19, the receptor for newly synthesized PMPs; autophagy-related protein 30 (Atg30), a protein involved in the selective breakdown of peroxisomes (pexophagy); and inheritance of peroxisomes protein 1 (Inp1), a protein important for peroxisome retention in mother cells. Here, we show that the overexpression of any of these proteins affects peroxisomal processes, with the level of overexpression being the primary determ

SUBMITTER: de Lange EMF 

PROVIDER: S-EPMC12797020 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature