Crotonylation and the Risk of Head and Neck Cancer: Insights from a Two-Sample Mendelian Randomization Study.

ABSTRACT:

Background

Head and neck cancer (HNC) remains a major global health burden with limited improvement in survival. Crotonylation has been implicated in tumour biology, but its causal contribution to HNC risk is unclear.

Methods

We conducted a two-sample Mendelian randomization (MR) study using expression quantitative trait loci (eQTL)-instrumented expression of crotonylation-related genes. Differential expression was assessed in The Cancer Genome Atlas (TCGA). Mediation MR evaluated 1,400 metabolites and 731 immune-cell traits. Single-cell RNA sequencing (scRNA-seq) mapped cell type - specific expression, and quantitative PCR (qPCR) validated expression in tumour versus normal tissues.

Results

MR analysis identified that genetically predicted expression of Glutaryl-CoA

SUBMITTER: Zhang D 

PROVIDER: S-EPMC12797063 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature