Intake of a cetoleic acid concentrate lowered concentrations of markers of inflammation and macrophage infiltration but did probably not increase EPA biosynthesis in male obese Zucker fa/fa rats.

ABSTRACT: Obesity is characterised by chronic low-grade inflammation, which is a key factor in the development of obesity-related co-morbidities. Intake of n-3 long-chain PUFAs is associated with anti-inflammatory effects. Recent studies suggest that also n-11 long-chain MUFAs may reduce the concentrations of inflammatory markers, possibly by increasing the biosynthesis of EPA. The primary aim was to investigate if diets added herring oil containing cetoleic acid (CA, C22:1n-11) or a CA concentrate (CECO) affected the fatty acid composition in tissues from obese rats with chronic inflammation. Secondary aims included investigating the effects on inflammatory markers. Thirty male obese Zucker fa/fa rats were fed diets containing herring oil (HERO) or a CECO, containing 0·70 or 1·

SUBMITTER: Hansen A 

PROVIDER: S-EPMC12797074 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature