Hybrid Nerve Sheath Tumor Detected by Endoscopic Full-Thickness Resection for a Gastric Subepithelial Lesion: A Case Report.

ABSTRACT: Hybrid nerve sheath tumors (HNSTs) are exceedingly rare in the gastrointestinal tract, particularly in the stomach. We describe a case of an enlarging gastric subepithelial lesion (SEL) that was accurately diagnosed and curatively treated by endoscopic full-thickness resection (EFTR). A 50-year-old woman presented with a 10 mm SEL on the posterior wall of the upper gastric curvature. Endoscopic ultrasound (EUS) revealed a low-hypoechoic lesion primarily originating from the third layer with focal, indistinct borders with the muscularis propria. Initial boring biopsy suggested a granular cell tumor based on morphology and SOX10/S100 positivity. Six months later, the lesion had enlarged to 15 mm, and EFTR under general anesthesia with laparoscopic backup was selected to obtain a full-thickne

SUBMITTER: Fukuda M 

PROVIDER: S-EPMC12797082 | biostudies-literature | 2026 Apr

REPOSITORIES: biostudies-literature