Maternal Pregnancy Outcomes and Offspring Risk of Adult-Onset Multiple Sclerosis.

ABSTRACT:

Importance

Although concordance rates for multiple sclerosis (MS) are higher among dizygotic twins than among nontwin siblings-suggesting a potential influence of prenatal and perinatal factors-few large-scale studies have systematically investigated the role of maternal adverse pregnancy outcomes in risk of MS in offspring.

Objective

To explore whether preterm birth, being born small or large for gestational age (SGA and LGA, respectively), maternal hypertensive disorders of pregnancy (HDP), placental abruption, and maternal diabetes are associated with the risk of adult-onset MS in offspring.

Design, setting, and participants

A closed cohort study with a follow-up beginning in January 2009 and continuing until the first event, death, emigration, or end of follow-up

SUBMITTER: Wolfova K 

PROVIDER: S-EPMC12797129 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature