Hippocampal Subfield Susceptibility Alterations in Mild Cognitive Impairment Revealed by 7T MRI.

ABSTRACT:

Background and purpose

Hippocampal magnetic susceptibility alterations may serve as early neurodegenerative biomarkers of Alzheimer's disease (AD), but subfield-level evidence in mild cognitive impairment (MCI) remains limited. This study utilizes submillimeter high-resolution quantitative susceptibility mapping (QSM) to investigate hippocampal subfield susceptibility changes in MCI.

Materials and methods

Thirteen individuals with MCI and thirteen cognitively normal controls (NC) underwent 7T MRI scans including Magnetization-Prepared Two Rapid Acquisition Gradient Echoes (MP2RAGE) and multi-echo Gradient Echo (GRE) imaging (for QSM). Visibility of hippocampal strata radiatum, lacunosum, and moleculare (SRLM) was assessed using a visual rating scale. Hippocampal subfields (C

SUBMITTER: Zheng G 

PROVIDER: S-EPMC12797140 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature