Considering brain state for individualized functional connectivity-based rTMS.

ABSTRACT: Recent endeavors to optimize the efficacy of repetitive Transcranial Magnetic Stimulation (rTMS) treatment have focused on locating individualized stimulation targets using functional connectivity derived from functional Magnetic Resonance Imaging (fMRI) scans. Practically, this approach involves three main stages: target discovery, target localization, and treatment. As of now, each stage is typically conducted while participants are "at rest", meaning they are not performing a task or being presented with a stimulus. While growing evidence suggests that the effects of TMS are sensitive to the state of the brain at the time of stimulation, brain state has largely been overlooked during the first two stages (target discovery and localization). Here, we consider the potential importance of

SUBMITTER: Shearer H 

PROVIDER: S-EPMC12797142 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature