Determinants of publication likelihood and timeliness for clinical studies.

ABSTRACT:

Introduction

Timely dissemination of clinical trial results is essential to advance knowledge, guide practice, and improve outcomes, yet many trials remain unpublished, limiting impact. We examine what drives publication and timelines across three major clinical domains.

Methods

We analyzed study design and factors associated with dissemination of interventional trials, focusing on cardiovascular disease (CVD), cancer, and COVID-19. A total of 10,785 trials (CVD: 5929; cancer: 4210; COVID-19: 646) were linked to PubMed publications using National Clinical Trial identifiers. Study design, operational, and transparency-related features were assessed as predictors of time to publication, defined as the interval from study completion to first publication, using Cox proportional

SUBMITTER: Wang H 

PROVIDER: S-EPMC12797179 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature