Esterification synthesis of iron oxide nanoparticle tracers for magnetic particle imaging (MPI).

ABSTRACT: The potential for producing iron oxide magnetic particle imaging (MPI) tracers using an alternative synthesis method based on esterification of iron oleate with oleyl alcohol was evaluated. The defined reaction mechanism allows monitoring of reaction progress with Fourier Transform Infrared (FTIR) spectroscopy. The influence of reaction temperature and precursor flow rate on esterification reactions of Fe(II) oleate for tuning iron oxide nanoparticle size and dispersity was studied, identifying conditions for producing larger nanoparticles suitable as MPI tracers. Increasing temperature and decreasing flow rates were found to increase the resulting nanoparticle size and reduce dispersity. Furthermore, the effect of the iron source used to prepare the iron oleate precursor was evaluated by

SUBMITTER: Velazquez-Albino AC 

PROVIDER: S-EPMC12797196 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature