RYGB induces vagal sensory neuropathy characterized by altered Glp1r expression and enhanced exendin-4 responsiveness in male mice.

ABSTRACT: The effects of Roux-en-Y gastric bypass (RYGB) on the gut-brain axis remain poorly understood. This study specifically explores phenotypic changes in vagal afferent neurons in male obese C57BL/6J mice following RYGB. Our results show that RYGB induced the expression of activating transcription factor 3 (Atf3) mRNA-a well-established marker of axonal injury-in a subset of vagal sensory neurons. In addition, RYGB led to a significant reduction in both the proportion of vagal afferents expressing the glucagon-like peptide 1 receptor (GLP1R) and the overall Glp1r mRNA levels in the nodose ganglion. Nerve transection experiments replicated these changes, suggesting that axonal injury alone may account for the observed phenotypic alterations in vagal afferent neurons following RYGB

SUBMITTER: Merchant W 

PROVIDER: S-EPMC12797217 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature