Patterns of prostate recurrence after focal salvage prostate brachytherapy for radiorecurrent prostate cancer.

ABSTRACT:

Background and purpose

Focal high-dose-rate (HDR) salvage brachytherapy has emerged as a treatment for radiorecurrent prostate cancer. This study aims to evaluate patterns of recurrence after focal salvage brachytherapy and to assess the adequacy of current treatment margins.

Materials and methods

Between March 2015 and December 2021, 39 patients with radiorecurrent prostate cancer underwent focal HDR brachytherapy. All patients had biopsy-confirmed local recurrence and were staged using Choline- or PSMA-PET/CT and multiparametric MRI. A 5 mm margin around the GTV was applied to define the CTV. Post-treatment recurrences were analyzed using rigid image registration of PET/CT and MRI to assess spatial relationships among the initial recurrence (Rec1), the recurrence following

SUBMITTER: Dominguez AD 

PROVIDER: S-EPMC12797306 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature