Protective Role of Dietary Short-Chain Fatty Acid Propionate against Autoimmune Responses and Pathology of Systemic Lupus Erythematosus in MRL-lpr Mice.

ABSTRACT:

Background

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that affects multiple organs, including the skin and kidneys. The etiology of SLE remains unclear but involves hormonal, environmental, and genetic factors. Environmental factors, such as diet and microbiota-derived metabolites, among which short-chain fatty acids (SCFAs) are major players, can influence autoimmune disease pathogenesis.

Objectives

This study investigates the involvement of SCFAs in the pathogenesis of SLE and further investigates the effect of propionate (PA) supplementation on SLE disease outcome in MRL-lpr mice.

Methods

Cecal SCFAs from mouse models with varying degrees of SLE disease activities (C57BL/6, MRL+/+, and MRL-lpr) were determined by liquid chromatography/MS ana

SUBMITTER: Wang H 

PROVIDER: S-EPMC12797317 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature