Early fluid therapy trajectories in acute pancreatitis: a retrospective cohort study.

ABSTRACT:

Background

Individualized management of early fluid therapy in acute pancreatitis (AP) remains challenging. Traditional studies primarily focus on static fluid balance, overlooking the heterogeneity of dynamic trajectories.

Methods

Based on a single-center retrospective cohort, 3,142 AP patients admitted within 72 h of onset were included. Daily fluid therapy-to-body weight ratio (FWR) and CumFWR (trapezoidal AUC) were calculated. Latent Class Growth Modeling (LCGM) identified dynamic FWR trajectories within 72 h. Multivariate Cox regression analyzed the relationship between FWR and in-hospital mortality risk. Three-dimensional fitted surface plot analysis evaluated interactions between CumFWR and hematocrit.

Results

LCGM successfully identified five distinct dynamic

SUBMITTER: Wan J 

PROVIDER: S-EPMC12797337 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature