Evaluation of four chimeric Trypanosoma cruzi recombinant antigens for serological diagnosis of chronic Chagas disease in dogs: a phase II study.

ABSTRACT:

Background

Dogs are recognized as epidemiologically significant reservoirs for Trypanosoma cruzi, the causative agent of Chagas disease (CD), owing to their close association with humans and their role in sustaining the domestic and peridomestic transmission cycle. Canine seropositivity often correlates with human CD prevalence. However, the lack of commercial, high-performance diagnostic assays for canine infections remains a significant barrier to effective surveillance. Previously, our group demonstrated the diagnostic potential of four chimeric T. cruzi antigens in a phase I study, yielding results comparable to those observed in humans. The present phase II study expands upon these findings by evaluating these antigens in a larger canine cohort using indirect enzyme-linked imm

SUBMITTER: Fontes ND 

PROVIDER: S-EPMC12797350 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature