Multiplicity adjustment approaches in publicly funded multi-arm trials: a comprehensive review of the National Institute for Health and Care Research (NIHR) Journals Library.

ABSTRACT:

Background

Parallel-group multi-arm trials are randomised controlled trials (RCTs) where participants are allocated to three or more concurrent treatment groups. Multiplicity occurs when several statistical tests are conducted within the same study. Statistical adjustments to the design and analysis of multi-arm trials can be used to control the study-wise type I error rate. There is no clear guidance or consensus on the necessity of multiplicity adjustment in multi-arm trials, nor on which methods are most appropriate. This comprehensive review aimed to investigate the design, analysis and reporting of publicly funded parallel-group multi-arm trials and to report the approach to multiplicity in these trials with respect to sample size and statistical analysis.

Methods

We se

SUBMITTER: Lee EC 

PROVIDER: S-EPMC12797383 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature