Loss of ovarian hormones is detrimental in early disease stages of mouse models of Alzheimer's disease and multi-etiology dementia.

ABSTRACT:

Background

Up to 80% of Alzheimer's disease (AD) patients suffer from brain vascular damage resulting in multi-etiology dementia (MED). Sex is a well-known risk factor for dementia; out of three AD patients two are women. 17β-estradiol, a predominant ovarian hormone in woman before menopause, is known to have beneficial effects on the cerebrovasculature, neuroinflammation and neuroprotection. Here, we investigated the consequences of the loss of ovarian hormones caused by surgical menopause (ovariectomy) on AD and MED.

Methods

The App^NL-F knock-in mice were used to model AD. At about 5.5 months of age, a stage corresponding to early disease pathology, female App^NL-F mice were subjected to ovariectomy (OVX) or sham surgery (Intact) and left to recover fo

SUBMITTER: Abi-Ghanem C 

PROVIDER: S-EPMC12797386 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature