Hepatic steatosis in postmenopausal women is characterized by distinct serum extracellular vesicle proteomic signatures.

ABSTRACT:

Background

Metabolic dysfunction-associated steatotic liver disease (MASLD) is common among midlife women. Circulating extracellular vesicles (EVs) carry bioactive cargo that may mediate or reflect disease processes, but their role in hepatic steatosis in postmenopausal women remains unexplored.

Methods

We conducted liquid chromatography data-independent acquisition-mass spectrometry on serum-derived EVs from 275 postmenopausal women enrolled in the Michigan site of the Study of Women's Health Across the Nation (MI-SWAN). Participants were grouped by hepatic steatosis status (n = 75), assessed via standardized ultrasound at the 2010 follow-up visit. Fasting serum samples were processed using size exclusion chromatography to isolate EVs. Differential EV protein abundance was

SUBMITTER: Pirrotte P 

PROVIDER: S-EPMC12797421 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature