Simultaneous Pancreas-Kidney Versus Kidney Transplant Alone: Real-World Outcomes in a Propensity-Matched Global Cohort.

ABSTRACT: The true comparative effectiveness of simultaneous pancreas-kidney transplantation (SPKT) versus kidney transplantation alone (KTA) in patients with diabetes and end-stage renal disease remains incompletely defined. Using the TriNetX Global Collaborative Network (2010-2024), we identified 3,679 SPKT and 27,062 KTA recipients aged 18-59 years. In unmatched comparisons, SPKT recipients showed lower mortality, fewer cardiovascular events, and improved kidney graft survival relative to KTA recipients, but also higher early rejection, infection, and readmission rates. After 1:1 propensity score matching, the cohorts were well balanced across all measured covariates, and long-term estimates for survival (HR 1.00, 95% CI 0.90-1.10), kidney graft failure (HR 0.99, 95% CI 0.94-1.04), and cardiovasc

SUBMITTER: Catarinella D 

PROVIDER: S-EPMC12797426 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature