Genome-wide methylation profiles of primary and matched distant metastasis: insights from the Dutch Early-Stage melanoma (D-ESMEL) study.

ABSTRACT:

Background

Early-stage (stage I-II) cutaneous melanoma accounts for the majority of melanoma diagnoses. However, more than 40% of patients who die due to melanoma were initially diagnosed with an early-stage melanoma. This highlights the current limitations of the Tumor Node Metastasis (TNM) staging and shows that additional biomarkers, prognostic for distant metastasis, need to be identified.

Methods

The aim of this study was to identify prognostic genome-wide methylation markers of metastasized primary early-stage melanomas and retrieving biological insights from its matched distant metastasis. We selected 45 samples from the Dutch Early-Stage Melanoma (D-ESMEL) study, representing case-control sets where the primary melanoma of each metastatic case (n = 15) is matched to

SUBMITTER: Ouwerkerk J 

PROVIDER: S-EPMC12797433 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature