Systems genetics of lifespan and senescence in Drosophila melanogaster.

ABSTRACT:

Background

As populations age, the number of people with age-related chronic diseases increases, causing significant social, economic and health problems. Natural variation in lifespan depends on multiple interacting genes and environmental exposures. Its short generation time and many resources make Drosophila melanogaster an advantageous model to uncover the genetic architecture that underlies variation in lifespan.

Results

We performed whole genome sequencing on young and old flies, sexes separately, in an outbred advanced intercross population (AIP) derived from inbred, sequenced lines from the Drosophila Genetic Reference Panel (DGRP). We identified mostly sex-specific variants (extreme Quantitative Trait Loci; xQTLs) at 1,107 genes associated with increased lifespan. W

SUBMITTER: Aghdam MN 

PROVIDER: S-EPMC12797436 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature