The impact of metformin on myocardial hypertrophy: an updated systematic review, meta-analysis, and meta-regression of randomized controlled trials.

ABSTRACT:

Background

Metformin is a cornerstone treatment for diabetes that has demonstrated significant cardioprotective effects. Studies in animals and humans supported metformin as an anti-remodeling drug by regulating molecular pathways involved in cardiac hypertrophy, as a strong, independent predictor of cardiovascular events and mortality. Herein, we aimed to systematically evaluate metformin's therapeutic potential on myocardial hypertrophy, a topic that remains argued and still lacks a consensus.

Methods

A systematic review and meta-analysis were conducted on randomized controlled trials (RCTs) following PRISMA guidelines (PROSPERO: CRD42024619803). PubMed, Scopus, Web of Science, and Embase databases were searched until June 2025. Primary outcomes were changes in left ventri

SUBMITTER: Azarboo A 

PROVIDER: S-EPMC12797440 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature